Webmap vanderbilt6/16/2023 ![]() logolink-URL to an external website or web resource.Clicking the thumbnail redirects to the URL set with the logolink parameter. logoimage-URL to an image that is used as a clickable thumbnail in the map layout.If the home parameter is set to true, the home button also moves according to the value of the zoom_position parameter. Valid options are top-left (default), bottom-left, top-right, or bottom-right. zoom_position-Determines the location of the zoom control buttons.popup_sidepanel-When set to true, pop-up information is presented on the info tab of the side panel instead of in the map.show_panel-When set to true, the side panel displays when the map loads.The legend or details parameter must be set to true if used as the value for the active_panel parameter. active_panel-Sets which tab is active in the side panel when the map loads.details-When set to true, the map’s description text appears in the side panel.legend-When set to true, a legend displays in the side panel showing the layers in the map.theme-Determines the color theme applied to the side panel and buttons.The following parameters give you control of the look and feel of the map: We aim to: 1) procure and manage human tissue specimens 2) determine and mitigate non-biological pre-analytical factors and 3) develop scalable multimodal imaging and deep multi-omic assays for the human kidney.If any of the resources in the URL parameter are provided as HTTP, you must replace HTTP with HTTPS in the URL and make all resources accessible using HTTPS only. The mission of BIOMIC is to build a platform of integrated technologies for imaging and molecular analysis to enable the construction of comprehensive 3D molecular atlases of human tissues. This application proposes the continuation of the Biomolecular Multimodal Imaging Center (BIOMIC) at Vanderbilt University, a Tissue Mapping Center associated with the Human BioMolecular Atlas Program (HuBMAP). Our methods of integrating imaging mass spectrometry, highly multiplexed immunofluorescence microscopy, autofluorescence microscopy, stained microscopy, spatial transcriptomics, spatial proteomics, and single-cell RNA-seq to create comprehensive 2D and 3D molecular and cellular atlases of the human kidney will have a great impact on the research community. The goal of the proposed kidney TMC is to create atlases for community users, physicians, and researchers to use as a guide to navigate the molecular landscape of the kidney, generate novel hypotheses, and tackle meaningful biomedical research questions. This multidisciplinary effort requires the creation and integration of three capabilities to: 1) procure and manage human tissue specimens 2) determine and mitigate non-biological pre-analytical factors and 3) acquire, process, and disseminate multimodal 3D imaging and large-scale omics data. As a HuBMAP participant, the molecular atlases produced by this TMC will be disseminated to the community and to collaborators to generate new hypotheses regarding the function of this important organ system, enabling new insight into human health and disease. ![]() The application of this multimodal pipeline to the kidney will provide a new paradigm of understanding the normal state of this organ across multiple dimensions, both molecular (e.g., lipids, metabolites, proteins, and transcripts) and spatial (e.g., whole organs to single cells). Through segmentation and cell type analysis determined by classical markers, we will correlate our molecular and clinical information to the existing knowledge of the kidney to better define the normal phenotypes across a range of diverse samples. In addition, we will utilize the resources of the advanced biocomputational infrastructure available through the Data Analysis Core laboratories at Vanderbilt University and the Delft University of Technology, Netherlands. We will leverage the unique resources of the Mass Spectrometry Research Center and the National Research Resource for Imaging Mass Spectrometry at Vanderbilt University and Vanderbilt University Medical Center. ![]() Our mission is to build a platform of integrated technologies for imaging and molecular analysis to enable the construction of comprehensive 3D molecular atlases of the human kidney. This application proposes the continuation of a Tissue Mapping Center (TMC) for the human kidney within the Human BioMolecular Atlas Program (HuBMAP).
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